If you are in the depths of despair, you are extremely unhappy.

Don't despair; things will get better soon.

不必绝望, 事情不久就会好起来.

He was prey to a growing despair.

他被与日俱增的绝望折磨着。

They frequently plumb the depths of loneliness, humiliation and despair.

他们常常陷入孤独、屈辱和绝望的深渊。

The rejection plunged her into the dark depths of despair.

遭到拒绝使她陷入了绝望的深渊.

The bandit chief surrendered himself to despair and took his own life.

匪首在绝望中自杀了.

He was then depressed and in despair.

他那时沮丧郁闷,情绪低落.

He was plunged into despair by the terrible news.

这个可怕的消息使他突然陷于绝望之中.

They fought with the courage of despair.

他们作殊死搏斗.

Tiredness and despair were etched into his face.

疲乏与失望刻在他的脸上.

He gave up the attempt in despair.

他在绝望中放弃了这种尝试.

This boy is his mother's despair.

这个男孩使他妈绝望了.

He alternated between hope and despair.

他时而充满希望,时而绝望.

I would overcome any weakness, any despair, any fear.

我要克服所有的软弱、绝望和恐惧。

His mother flung up her hands in despair when the boy failed yet another examination.

当孩子考试又不及格时,母亲感到毫无希望了.

This poem runs the gamut of emotions from despair to joy.

这首诗展现了从绝望到喜悦的感情历程.

Don't let yourself despair; this will only make matters worse.

不要想不开，这样只能使情况变得更糟。

Despair overclouded his face.

绝望使他的脸色阴沉.

He looked at the telephone, fighting down first the despair and then the anger.

他看着电话，把绝望和愤怒一一压下。

I looked at my wife in despair.

我绝望地看着妻子。

His moods kept changing — now happy, now filled with despair.

他情绪多变——时而高兴, 时而感到绝望.