anxiolytic

Studies on the Anxiolytic Effect of Succinic Acid

琥珀酸的抗焦虑作用研究

I 20 failed to affect the locomotor activity in mice in the test dose ( 20 mg · kg-1, ip), suggesting I 20 did not induce sedation in the anxiolytic doses.

I20在实验剂量下（20mg·kg-1，ip）对小鼠自主活动性无影响，表明该化合物在抗焦虑的剂量下无镇静的副作用。

Dexmedetomidine is a new type of high selective α 2-adrenergic receptor agonists, which has sedative, analgesic and anxiolytic effects, can maintain hemodynamic stability, has no respiratory depression, amnesia after surgery and son on.

右美托咪定是一种新型、高选择性α2肾上腺素能受体激动剂，具有镇静镇痛、抗焦虑、稳定血流动力学、无呼吸抑制、术后遗忘等作用。

AIM: To investigate the influence of sulfated polysaccharide from brown seaweed on the spontaneous activity in mice, then evaluate its anti-convulsive, hypnotic, and anxiolytic effects.

目的：观察褐藻多糖对小鼠自发活动的影响，评价其抗惊厥，催眠和抗焦虑的作用。

There was no difference between the anxiolytic effects, sedative effects, amnestic effects of the four groups ( P> 0 05).

实验组四组间手术前后焦虑变化情况、镇静评分、健忘评分差异无显著性（P＞0.05）。

Designed to examine the retention of shock induced fear the system provides all components necessary to investigate into anxiolytic drugs.

用于检测恐惧记忆的系统，能提供调查焦虑性药物的所有必须成分。

During open field test, none of the three doses of diazepam administration showed any significant anxiolytic effects.

在旷场测试中，不同剂量的diazepam抗焦虑效果则不明显。

Studies on Anxiolytic Constituents of Scutellaria Baicalensis Georgi

黄芩抗焦虑活性成分研究

Meanwhile to investigate the effects of anxiolytic drug on symptoms of ulcerative colitis rats under psychological stress and the mechanisms of it.

同时观察抗焦虑药物对处于应激状态下溃疡性结肠炎大鼠症状的干预作用及其作用机制。

Furthermore, the net effect of clinically-relevant repeated treatment with anxiolytic/ antidepressant drugs, regardless of chemical class, appears to reflect an enhancement of 5-HT neurotransmission in forebrain targets, most notably in the hippocampus.

此外，临床上用相应的抗焦虑/抗忧郁药剂重复处理，在前脑的作用表现为增进5-HT的神经传导，尤以海马最显著。

The antidepressant-and anxiolytic effects of asarone ( AN) were investigated by means of behavioral pharmacology for the first time.

摘要本课题主要运用行为药理学手段研究了细心脑（asarone，AN）的抗抑郁和抗焦虑作用及其对中枢系统的其它作用。

Antidepressant and anxiolytic effect of compound yujin capsule

复方郁金胶囊抗抑郁抗焦虑的作用

To study the effects of buspirone, a selective anxiolytic drugs, on acquisition and retention, mice were trained and tested on step through passive avoidance and two way active avoidance learning tasks.

应用小鼠一次性被动回避和穿箱主动回避行为法，观察抗焦虑剂丁螺环酮（Bus）对学习获得和记忆保持的影响。

Objective: to investigate the anxiolytic effect of nifedipine in the treatment of morphine dependent rats.

目的··：评价钙拮抗剂硝苯地平对戒断后期焦虑症状及复吸的治疗作用。

MCPP-induced Anxiety Model in Light-dark Box in ddy Mice& A New Economic and Simple Method for Screening Anxiolytic Activity

ddy小鼠替代大鼠的经济简便的抗焦虑药筛选改进模型&间氯苯哌嗪诱导的小鼠明暗箱焦虑模型

AIM To investigate the anxiolytic effect and mechanism of action of the indo derivative I 20, a ligand of the peripheral benzodiazepine receptor.

目的研究外周型苯二氮卓受体配基吲哚衍生物I20的抗焦虑作用及作用机制。

Conclusion The results suggest that it is effective of bupropion in treating depression, with fewer side effects and less anxiolytic effects in comparison with amitriptyline.

结论国产安非他酮片治疗抑郁障碍有效，不良反应少于阿米替林，但疗效尤其是抗焦虑等作用不如阿米替林。

After pretreatment with the anxiolytic drug diazepam ( 5mg/ ml, 5mg/ kg), the entries to the open arms and the time stoped in the open arms were increased significantly in the elevated plus-maze test.

腹腔注射抗焦虑药物安定（5mg/ml，5mg/kg）治疗以后，大鼠在高架十字迷宫实验中进入开放壁的次数和在开放壁停留时间显著增多。

The data of Vogel's conflict indicated that anxiolytic effects of sulfated polysaccharide from brown seaweed at dose of 61.78, 185.34 and 556.02 mg/ kg had a typical bell-curve dose-effect relationship with the effective dose of 185.34 mg/ kg.

进一步的Vogel冲突实验显示，褐藻多糖在61.78185.34和556.02mg/kg剂量下其抗焦虑作用呈现典型的钟型剂量-效应关系，有效剂量为185.34mg/g。

Aim To find out synthetic methods for AF-5 that is a potent anxiolytic under development.

目的AF5是正在研究、开发的抗焦虑药，本文探讨其合成方法。

Anxiolytic intervention for coronary heart disease patients combined with anxiety disorder

合并焦虑障碍冠心病患者介入治疗后抗焦虑干预的效果

Results Totally twelve 4-substituted α-agarofuran derivatives were synthesized and it was found that this kind of compounds had anxiolytic and sedative effects.

结果合成了12个4位取代的α沉香呋喃衍生物，其中10个为新化合物。药理试验结果表明：部分该类化合物具有抗焦虑作用和轻度的中枢神经抑制作用。